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KMID : 0359920150340010057
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Korean Journal of Nephrology
2015 Volume.34 No. 1 p.57 ~ p.59
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Immunoglobulin E-mediated hypersensitivity reaction after intraperitoneal administration of vancomycin
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Hwang Mun-Ju
Do Jun-Young
Choi Eun-Woo
Seo Joon-Hyuk
Nam Yoon-Jung
Yoon Kyung-Woo
Park Jong-Won
Cho Kyu-Hyang
Kang Seok-Hui
Jin Hyun-Jung
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Abstract
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Intraperitoneal (IP) vancomycin is widely used to treat Gram-positive peritonitis associated with peritoneal dialysis. There have been two cases of red man syndrome (RMS), a vancomycin-specific nonimmunologic reaction, associated with IP vancomycin. However, immune-mediated hypersensitivity reaction to IP vancomycin has not yet been reported. A 49 year old woman on continuous ambulatory peritoneal dialysis developed her first peritonitis episode. The patient was treated with IP vancomycin once/wk for 4 weeks. She experienced mild itching and flushing throughout her body for 1 day after the second treatment. Whenever vancomycin was administered, generalized urticaria and a prickling sensation developed, and the intensity increased gradually; however, these symptoms improved after vancomycin was discontinued. An allergic skin test was performed 6 weeks after the previous urticarial episode, and an intradermal skin test revealed a positive
response to vancomycin. To our knowledge, this is the first case report of immunoglobulin E-mediated hypersensitivity reaction to IP vancomycin administration.
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KEYWORD
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Hypersensitivity, Intraperitoneal administration, Peritoneal dialysis, Vancomycin
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